Based on the unique mechanism of action of TTFields, multiple pre-clinical and clinical studies investigating the efficacy and safety of TTFields in a range of cancer types have been initiated, including1-6:
| Trial | Pre-clinical | Phase II Pilot | Phase III Pivotal | Status | Estimated Enrollment | Estimated Completion |
|---|---|---|---|---|---|---|
A phase III study of TTFields following stereotactic radiosurgery for 1-10 brain metastases from non-small cell lung cancer more… |
|
Recruiting | 270 | Dec 2020 | ||
A phase III study of TTFields combined with chemotherapy for advanced non-small cell lung cancer progressed during or after platinum-based therapy more… |
|
Recruiting | 534 | Dec 2021 | ||
A phase III study of TTFields combined with chemotherapy for newly-diagnosed pancreatic cancer more… |
|
Recruiting | 556 | Dec 2022 | ||
A phase III study of TTFields combined with chemotherapy for platinum-resistant ovarian cancer more… |
|
Recruiting | 540 | Dec 2024 | ||
A phase II study of TTFields combined with sorafenib for advanced hepatocellular cancer more… |
|
Recruiting | 25 | Dec 2020 | ||
|
EF-31 A phase II study of TTFields combined with chemotherapy for unresectable gastroesophageal junction or gastric cancer more… |
|
Recruiting | 28 | Dec 2022 | ||
All six trials have passed the pre-clinical testing stage. Clinical trial data can be expected from the four ongoing phase III pivotal studies in the near future.
References:
- National Institutes of Health U.S National Library of Medicine. LUNAR trial. Available at: https://clinicaltrials.gov/ct2/show/NCT02973789?term=lunar. Accessed 11 March, 2020.
- National Institutes of Health U.S National Library of Medicine. HEPANOVA trial. Available at: https://clinicaltrials.gov/ct2/show/NCT03606590. Accessed 11 March, 2020.
- National Institutes of Health U.S National Library of Medicine. PANOVA-3 trial. Available at: https://clinicaltrials.gov/ct2/show/NCT03377491. Accessed 11 March, 2020.
- National Institutes of Health U.S National Library of Medicine. ENGOT-ov50/GOG-3029/INNOVATE-3 trial. Available at: https://clinicaltrials.gov/ct2/show/NCT03940196. Accessed 11 March, 2020.
- National Institutes of Health U.S National Library of Medicine. METIS trial. Available at: https://clinicaltrials.gov/ct2/show/NCT02831959. Accessed 11 March, 2020.
- National Institutes of Health U.S National Library of Medicine. EF-31 trial. Available at: https://clinicaltrials.gov/ct2/show/NCT04281576. Accessed 11 March, 2020.