Ongoing Clinical Trials

Based on the unique mechanism of action of TTFields, multiple pre-clinical and clinical studies investigating the efficacy and safety of TTFields in a range of cancer types have been initiated, including1-6:

Trial Pre-clinical Phase II Pilot Phase III Pivotal Status Estimated Enrollment Estimated Completion

A phase III study of TTFields following stereotactic radiosurgery for 1-10 brain metastases from non-small cell lung cancer more…

Recruiting 270 Dec 2020

A phase III study of TTFields combined with chemotherapy for advanced non-small cell lung cancer progressed during or after platinum-based therapy more…

Recruiting 534 Dec 2021

A phase III study of TTFields combined with chemotherapy for newly-diagnosed pancreatic cancer more…

Recruiting 556 Dec 2022

A phase III study of TTFields combined with chemotherapy for platinum-resistant ovarian cancer more…

Recruiting 540 Dec 2024

A phase II study of TTFields combined with sorafenib for advanced hepatocellular cancer more…

Recruiting 25 Dec 2020

EF-31

A phase II study of TTFields combined with chemotherapy for unresectable gastroesophageal junction or gastric cancer more…

Recruiting 28 Dec 2022

All six trials have passed the pre-clinical testing stage. Clinical trial data can be expected from the four ongoing phase III pivotal studies in the near future.

References:

  1. National Institutes of Health U.S National Library of Medicine. LUNAR trial. Available at: https://clinicaltrials.gov/ct2/show/NCT02973789?term=lunar. Accessed 11 March, 2020.
  2. National Institutes of Health U.S National Library of Medicine. HEPANOVA trial. Available at: https://clinicaltrials.gov/ct2/show/NCT03606590. Accessed 11 March, 2020.
  3. National Institutes of Health U.S National Library of Medicine. PANOVA-3 trial. Available at: https://clinicaltrials.gov/ct2/show/NCT03377491. Accessed 11 March, 2020.
  4. National Institutes of Health U.S National Library of Medicine. ENGOT-ov50/GOG-3029/INNOVATE-3 trial. Available at: https://clinicaltrials.gov/ct2/show/NCT03940196. Accessed 11 March, 2020.
  5. National Institutes of Health U.S National Library of Medicine. METIS trial. Available at: https://clinicaltrials.gov/ct2/show/NCT02831959. Accessed 11 March, 2020.
  6. National Institutes of Health U.S National Library of Medicine. EF-31 trial. Available at: https://clinicaltrials.gov/ct2/show/NCT04281576. Accessed 11 March, 2020.
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